Abstract
THE Rauscher leukaemia virus (RLV) induces a rapidly developing fatal erythroblastosis in mice, characterized by splenomegaly and a highly increased number of nucleated red cells in the peripheral blood1. The first sign of action of the virus is the production of erythroblast foci in the spleen within a week2. A linear dose-response relationship for virus and number of foci has been observed in several mouse strains, suggesting that a colony can be initiated by a single infective unit2.
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BENTVELZEN, P., AARSSEN, A. & BRINKHOF, J. Defectivity of Rauscher Murine Erythroblastosis Virus. Nature New Biology 239, 122–123 (1972). https://doi.org/10.1038/newbio239122a0
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DOI: https://doi.org/10.1038/newbio239122a0
