Abstract
IT is generally accepted that two distinct classes of lymphocytes collaborate in many immune functions. These lymphocytes are thymus-derived T cells and bone marrow-derived B cells. In mice T and B cells can be distinguished serologically; for example, T cells contain a membrane bound antigen (θ)1 and B cells also have a specific antigenic marker1. In addition, B cells have numerous surface bound immunoglobulin-like molecules which are readily demonstrable with labelled anti-sera2–6, but on T cells surface immunoglobulins are sparse and difficult to demonstrate3,5,7. Marked differences therefore exist between the membranes of T and B cells which cannot be seen directly in ultra-thin sections examined by electron microscopy. In this study, freeze-fracturing was used to produce replicas of the membranes of lymphocytes from normal and T cell-depleted mice in an attempt to demonstrate directly possible intramembraneous differences between T and B cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Raff, M. C., Transplant. Rev., 6, 52 (1971).
Wigzell, H., Transplant. Rev., 5, 76 (1970).
Raff, M. C., Sternberg, M., & Taylor, R. B., Nature, 225, 553 (1970).
Pernis, B., Forni, L., & Amante, L., J. Exp. Med., 132, 1001 (1970).
Rabellino, E., Colon, S., Grey, H. W., & Unanue, E. R., J. Exp. Med., 133, 156 (1971).
Bankhurst, A., & Warner, N. L., J. Immunol., 107, 368 (1971).
Nossal, G. J. V., Warner, N. L., Lewis, H., & Sprent, J., J. Exp. Med., 135, 405 (1972).
Moor, H., Z. Zellforsch., 62, 546 (1964).
Branton, D., Proc. US Nat. Acad. Sci., 55, 1048 (1966).
Pinto da Silva, P., & Branton, D., J. Cell Biol., 45, 598 (1970).
Tillack, T. W., & Marchesi, V. T., J. Cell Biol., 45, 649 (1970).
Raff, M. C., & Owen, J. J. T., Europ. J. Immunol., 1, 27 (1971).
Raff, M. C., Immunology, 19, 637 (1970).
Tillack, T. W., Scott, R. E., & Marchesi, V. T., J. Cell Biol., 47, 213a (1970).
Speth, V., Wallach, D. F. H., Wiedekamm, E., & Knüfermann, H., Biochim. Biophys. Acta, 255, 386 (1972).
Pinto da Silva, P., Douglas, S. D., & Branton, D., Nature, 232, 194 (1971).
Aoki, T., Hämmerling, U., de Harven, E., Boyse, E. A., & Old, L. J., J. Exp. Med., 130, 979 (1969).
Gilula, N. B., Branton, D., & Satir, P., Proc. US Nat. Acad. Sci., 67, 213 (1970).
Revel, J. P., Yee, A. G., & Hudspeth, A. J., Proc. US Nat. Acad. Sci., 68, 2924 (1971).
Gilula, N. B., Reeves, O. R., & Steinbach, A., Nature, 235, 262 (1972).
Singer, S. J., & Nicholson, G. L., Science, 175, 720 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MANDEL, T. Intramembraneous Marker in T Lymphocytes. Nature New Biology 239, 112–114 (1972). https://doi.org/10.1038/newbio239112a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio239112a0
This article is cited by
-
Glycerol increases the cytochemical detectability of cholesterol in the apical plasma membrane of uterine epithelial cells
Histochemistry (1987)
-
The lymphocyte plasma membrane: Locus of control in the immune response
In Vitro (1976)
-
Acetylcholinesterase in erythrocytes and lymphocytes: Its contribution to cell membrane structure and function
Experientia (1976)
-
Light-microscopical demonstration of different cell membrane structures of human peripheral blood lymphocytes (PBL)
Klinische Wochenschrift (1975)
-
Induced redistribution of membrane particles, anionic sites and con A receptors in Entamoeba histolytica
Nature (1974)
