Abstract
THE DNA of cells exposed to ionizing radiation incurs strand breaks and certain other types of damage (for review see ref. 1). Single-strand breaks are repaired both in prokaryotes2,3 and in eukaryotes4–6. But although double-strand break repair has been reported for phage DNA in lambda phage-infected bacteria7, for the radioresistant bacterium Micrococcus radiodurans8, and for the Chinese hamster ovary cell9, this type of repair has not been demonstrated in other bacterial species3 and mammalian cell lines5,6,10, suggesting that double-strand, rather than single-strand breaks are the lesions primarily responsible for the lethal effects of ionizing radiation3,6,11.
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BREWER, E., NYGAARD, O. Correlation between Unrepaired Radiation-induced DNA Strand Breaks and Mitotic Delay in Physarum polycephalum. Nature New Biology 239, 108–110 (1972). https://doi.org/10.1038/newbio239108a0
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DOI: https://doi.org/10.1038/newbio239108a0