Abstract
THE replicon hypothesis put forward by Jacob, Brenner and Cuzin1 postulated two elements involved in initiation of chromosomal replication: (1) a structure on the DNA, termed replicator, and (2) a diffusible factor (or factors)—called the initiator—which acts on the replicator to initiate replication.
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References
Jacob, F., Brenner, S., & Cuzin, F., Cold Spring Harbor Symp. Quant. Biol., 28, 329 (1963).
Stevens, W. F., Adhya, S., & Szybalski, W., The Bacteriophage Lambda (edit. by Hershey, A.), 515 (Cold Spring Harbor, 1971).
Dove, W. F., Inokuchi, H., & Stevens, W. F., The Bacteriophage Lambda (edit. by Hershey, A.), 747 (Cold Spring Harbor, 1971).
Joyner, A., Isaacs, L. N., Echols, H., & Sly, W. S., J. Mo. Biol., 19, 174 (1966).
Campbell, A., Virology, 14, 22 (1961).
Herskowitz, I., thesis, Cambridge, Massachusetts (1971).
Tomizawa, J., The Bacteriophage Lambda (edit. by Hershey, A.), 549 (Cold Spring Harbor, 1971).
Shuster, R. C., & Weissbach, A., Nature, 223, 852 (1969).
Freifelder, D., & Kirschner, I., Virology, 44, 223 (1971).
Dove, W. F., Hargrove, E., Ohashi, M., Haugli, F., & Guha, A., J. Genetics, 44, suppl. 1, 11 (1969).
Schaller, H., Otto, B., Nüsslein, V., Huf, J., Herrmann, R., & Bonhoeffer, F., J. Mol. Biol., 63, 183 (1972).
Kornberg, A., Science, 163, 1410 (1969).
Lindqvist, B. H., & Sinsheimer, R. L., J. Mol. Biol., 30, 69 (1967).
Wehrli, W., & Staehelin, M., Bact. Rev., 35, 290 (1971).
Brutlag, D., Schekman, R., & Kornberg, A., Proc. US Nat. Acad. Sci., 68, 2826 (1971).
Lark, K. G., J. Mol. Biol., 64, 47 (1972).
Winocour, E., Virology, 34, 571 (1968).
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KLEIN, A., POWLING, A. Initiation of λ DNA Replication in vitro. Nature New Biology 239, 71–73 (1972). https://doi.org/10.1038/newbio239071a0
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DOI: https://doi.org/10.1038/newbio239071a0
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