Abstract
SIGNIFICANT changes in RNA metabolism have been described during early sea urchin development. Until recently the only detectable class of RNA synthesized during cleavage stages was that with a low G + C base composition and heterogeneous sedimentation properties (DNA-Jike RNA)1. The genes for nucleolar ribosomal RNA (26S and 18S) were believed to become active only following gastrulation2–4, and the products of nuclear transfer RNA (4S) genes were first detected at the mesenchyme blastula stage5. Any label in the 4S region of sucrose gradients of RNA from the cleavage stages of embryogenesis was interpreted as reflecting the turnover of the pCpCpA region of pre-existing transfer RNA (tRNA) molecules.
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O'MELIA, A., VILLEE, C. De novo Synthesis of Transfer and 55 RNA1f in Cleaving Sea Urchin Embryos. Nature New Biology 239, 51–53 (1972). https://doi.org/10.1038/newbio239051a0
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DOI: https://doi.org/10.1038/newbio239051a0
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