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In vitro Blastogenesis inhibited by Erwinia carotovora L-Asparaginase

Nature New Biology volume 239, pages 50–51 (1972)Cite this article

Abstract

Escherichia coli L-asparaginase, an antileukaemic agent in man1, inhibits in vitro mitogen or antigen-induced blastogenesis in man2,3 and in animals (M. Bennett, E. G. Mayhew, and T. Han, unpublished data), and suppresses bone-marrow derived antibody precursor cells in the mouse4. We now report that another L-asparaginase preparation—from Erwinia carotovora—also possesses antileukaemic activity5,6, and has a more pronounced immunosuppressive effect on in vitro blastogenesis than the E. coli enzyme.

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Authors and Affiliations

  1. Department of Medicine, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York, 14203

    TIN HAN & TAKAO OHNUMA

Authors
  1. TIN HAN
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  2. TAKAO OHNUMA
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HAN, T., OHNUMA, T. In vitro Blastogenesis inhibited by Erwinia carotovora L-Asparaginase. Nature New Biology 239, 50–51 (1972). https://doi.org/10.1038/newbio239050a0

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