Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Cooperation within Actin Filament in Vertebrate Skeletal Muscle

Abstract

When actin molecules form “rigor complexes” with nucleotide-free myosin, tropomn binds calcium with greater affinity and in a cooperative response the remaining actin molecules not cornplexed with myosin are “turned on” even though calcium is absent.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ebashi, S., Endo, M., and Ohtsuki, I., Quart. Rev. Biophysics, 2, 351 (1969).

    Article  CAS  Google Scholar 

  2. O'Brien, E. J., Bennett, P. M., and Hanson, J., Phil. Trans. Roy. Soc. London, B, 261, 201 (1971).

    Article  CAS  Google Scholar 

  3. Tsuboi, K. K., Biochim. Biophys. Acta, 160, 420 (1968).

    Article  CAS  Google Scholar 

  4. Greaser, M. L., and Gergely, J., J. Biol. Chem., 246, 4226 (1971).

    CAS  PubMed  Google Scholar 

  5. Ebashi, S., Wakabayashi, T., and Ebashi, F., J. Biochem., 69, 441 (1971).

    Article  CAS  Google Scholar 

  6. Galen, De motu musculorum, 1.5 (k4: 391).

  7. Ebashi, S., Kodama, A., and Ebashi, F., J. Biochem., 64, 465 (1968).

    Article  CAS  Google Scholar 

  8. Ohtsuki, I., Masaki, T., Nomomura, Y., and Ebashi, S., J. Biochem., 61, 817 (1967).

    Article  CAS  Google Scholar 

  9. Bremel, R. D., thesis, St Louis University (1972).

  10. Weber, A., and Bremel, R. D., Contractility of Muscle Cells and Related Processes (edit. by Podolsky, R. J.) (Prentice Hall, Englewood Cliffs, New Jersey, in the press).

  11. Spudich, J. A., and Watt, S., J. Biol. Chem., 246, 4866 (1971).

    CAS  PubMed  Google Scholar 

  12. Kendrick-Jones, J., Lehman, W., and Szent-Györgyi, A. G., J. Mol. Biol., 54, 31 (1970).

    Article  Google Scholar 

  13. Lowey, S., Slayter, H. S., Weeds, A. G., and Baker, H., J. Mol. Biol., 42, 1 (1969).

    Article  CAS  Google Scholar 

  14. Young, M., Proc. US Nat. Acad. Sci., 58, 2393 (1967).

    Article  CAS  Google Scholar 

  15. Fuchs, F., and Briggs, F. N., J. Gen. Physiol., 51, 655 (1968).

    Article  CAS  Google Scholar 

  16. Bremel, R. D., Murray, J. M., and Weber, A., Cold Spring Harbor Symp. Quant. Biol. (in the. press).

  17. Bremel, R. D., and Weber, A., Biophysical Society Abstracts, 237a (1971).

  18. Hartshorne, D. J., and Pyun, Y. Y., Biochim. Biophys. Acta, 229, 698 (1971).

    Article  CAS  Google Scholar 

  19. Weber, A., Physiology and Biochemistry of Muscle as a Food (edit. by Briskey, E. J., Cassens, R. G., and Marsh, B. B.), 2, 383 (University of Wisconsin Press, Madison, Wisconsin, 1970).

    Google Scholar 

  20. Rumley, M. K., Armstrong, J. B., and Kennedy, E. P., Lactose Operon Meeting, Abstr., 26 (Cold Spring Harbor, New York, 1969).

  21. Maruyama, K., and Weber, A., Biochemistry (in the press).

  22. Hanson, J., and Huxley, H. E., Biochim. Biophys. Acta, 23, 250 (1957).

    Article  CAS  Google Scholar 

  23. Weber, A., Herz, R., and Reiss, I., Biochemistry, 8, 2266 (1969).

    Article  CAS  Google Scholar 

  24. Ebashi, S., and Ebashi, F., J. Biochem., 55, 604 (1964).

    Article  CAS  Google Scholar 

  25. White, D. C. S., J. Physiol., 208, 583 (1970).

    Article  CAS  Google Scholar 

  26. Reuben, J. P., Brandt, P. W., Berman, M., and Grundfest, H., J. Gen. Physiol., 57, 583 (1971).

    Article  Google Scholar 

  27. Levy, H. M., and Ryan, A. M., J. Gen. Physiol., 50, 2421 (1967).

    Article  CAS  Google Scholar 

  28. Weber, A., and Herz, R., J. Biol. Chem., 238, 599 (1963).

    CAS  Google Scholar 

  29. Weber, A., Herz, R., and Reiss, I., Proc. Roy. Soc., 160, 489 (1964).

    CAS  Google Scholar 

  30. Schliselfeld, L. H., and Barany, M., Biochemistry, 7, 3206 (1968).

    Article  CAS  Google Scholar 

  31. Lowey, S., and Luck, S. M., Biochemistry, 8, 3195 (1969).

    Article  CAS  Google Scholar 

  32. Lymn, R. W., and Taylor, E. W., Biochemistry, 10, 4617 (1971).

    Article  CAS  Google Scholar 

  33. Tonomura, Y., Watanabe, S., and Morales, M., Biochemistry, 8, 2171 (1969).

    Article  CAS  Google Scholar 

  34. Hartshorne, D. J., and Drelzen, P., Cold Spring Harbor Symp. Quant. Biol. (in the press).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BREMEL, R., WEBER, A. Cooperation within Actin Filament in Vertebrate Skeletal Muscle. Nature New Biology 238, 97–101 (1972). https://doi.org/10.1038/newbio238097a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio238097a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing