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Inhibition of Mitosis in Human Triploid Cells

Nature New Biology volume 238, pages 11–13 (1972)Cite this article

Abstract

TRIPLOIDY—the possession of three instead of two sets of chromosomes per cell-is a substantial cause of death in man. At least 1% of conceptions produce triploid zygotes, most of which are aborted by the end of the third month of pregnancy1. Only a few triploid infants are reported to have survived birth but the reason is not known. Death in utero also seems to be the fate of triploid rats, mice and rabbits2, but in amphibia3, Drosophila4 and many plants5,6, triploid individuals are not only viable but do not differ markedly from normal diploids.

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References

  1. Carr, D. H., J. Med. Genet., 8, 164 (1971).

    Article  CAS  Google Scholar 

  2. Beatty, R. A., Parthenogenesis and Polyploidy in Mammalian Development (Cambridge University Press, 1957).

  3. Fankhauser, G., Quart. Rev. Biol., 20, 20 (1945).

    Article  Google Scholar 

  4. Bridges, C. B., Science, 54, 252 (1921).

    Article  CAS  Google Scholar 

  5. Darlington, C. D., Evolution of Genetic Systems, second ed. (Oliver and Boyd, 1958).

  6. Avery, A. G., in Blakeslee: The Genus Datura (Ronald Press Co., New York, 1959).

    Google Scholar 

  7. Ellis, J. R., Marshall, R., Normand, I. C. S., and Penrose, L. S., Nature, 198, 411 (1963).

    Article  Google Scholar 

  8. Mittwoch, U., and Wilkie, D., Brit. J. Exp. Pathol., 53, 186 (1971).

    Google Scholar 

  9. Deeley, E. M., J. Sci. Instrum., 32, 263 (1955).

    Article  Google Scholar 

  10. Böök, J. A., and Santesson, E., Lancet, ii, 318 (1961).

    Article  Google Scholar 

  11. Ferrier, P., Ferrier, S., Stalder, G., Bühler, E., Bamatter, F., and and Klein, D., Lancet, i, 80 (1964).

    Article  Google Scholar 

  12. Schmid, W., and Vischer, D., Cytogenetics, 6, 145 (1967).

    Article  CAS  Google Scholar 

  13. Ford, C. E., in Cytogenetics of Cells in Culture (edit. by Harris, R. J. C), 27 (Academic Press, New York and London, 1964).

    Google Scholar 

  14. Fischberg, M., and Beatty, R. A., J. Exp. Zool., 118, 321 (1951).

    Article  Google Scholar 

  15. Piko, L., and Bomsel-Helmreich, O., Nature, 186, 737 (1960).

    Article  Google Scholar 

  16. Bomsel-Helmreich, O., in Advances in Biosciences, 6, Schering Symp. on Intrinsic and Extrinsic Factors in Early Mammalian Development (Pergamon Press, Oxford, 1970).

    Google Scholar 

  17. Anders, F., and Fahrig, R., Biol. Zentralblatt (Suppl.), 86, 465 (1967).

    Google Scholar 

  18. Butler, L. J., Chantier, C., France, N. E., and Keith, C. G., J. Med. Genet., 6, 413 (1969).

    Article  CAS  Google Scholar 

  19. Mittwoch, U., Delhanty, J. D. A., and Beck, F., Nature, 224, 1323 (1969).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Galton Laboratory, University College, London, WC1E 6BT

    URSULA MITTWOCH & JOY D. A. DELHANTY

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  1. URSULA MITTWOCH
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  2. JOY D. A. DELHANTY
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MITTWOCH, U., DELHANTY, J. Inhibition of Mitosis in Human Triploid Cells. Nature New Biology 238, 11–13 (1972). https://doi.org/10.1038/newbio238011a0

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