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Specific Binding of the Oestradiol-Receptor Complex to DNA

Nature New Biology volume 237, pages 204–206 (1972)Cite this article

Abstract

STUDIES on the interactions of steroid hormones with their target tissues have led to the generally accepted idea that hormone-receptor complexes are in some way involved in altering the pattern of DNA transcription1–12. The mechanism by which steroid-receptor complexes might regulate the transcription of the genome is, however, yet to be determined. It has been suggested that in the class of nuclear acidic proteins there are acceptor molecules which can bind specifically to the hormone-receptor complex and to DNA13. Other studies have indicated that the integrity of DNA is important for the binding of the hormone-receptor complex in nuclei14,15. The result of the binding of steroid-receptor complexes to DNA could presumably be the activation of a specific set of genes.

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Authors and Affiliations

  1. Department of Zoology, University of Michigan,

    L. E. CLEMENS & LEWIS J. KLEINSMITH

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  1. L. E. CLEMENS
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  2. LEWIS J. KLEINSMITH
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CLEMENS, L., KLEINSMITH, L. Specific Binding of the Oestradiol-Receptor Complex to DNA. Nature New Biology 237, 204–206 (1972). https://doi.org/10.1038/newbio237204a0

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