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Confirmation by Chemical Synthesis of the Structure of 4-Ipomeanol, a Lung-toxic Metabolite of the Sweet Potato, Ipomoea batatas

Nature New Biology volume 236, pages 158–159 (1972)Cite this article

Abstract

WE have described the lung and liver toxicity of mould-damaged sweet potatoes and characterized briefly some abnormal metabolites responsible for these phenomena1–4. The respiratory tract toxin, 4-ipomeanol (1-[3-furyl]-4-hydroxy-1-pentanone) (VI), may be responsible for the typical lung oedema of cattle that are fed mouldy sweet potatoes as well as a similar pathological state in mice fed or injected with the pure compound.

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Authors and Affiliations

  1. Department of Pharmacology, Division of Toxicology, School of Medicine, Department of Chemistry, Vanderbilt University, Nashville, Tennessee, 37232

    MICHAEL R. BOYD

  2. Division of Toxicology, School of Medicine, Department of Chemistry, Vanderbilt University, Nashville, Tennessee, 37232

    BENJAMIN J. WILSON

  3. Department of Chemistry, Vanderbilt University, Nashville, Tennessee, 37232

    THOMAS M. HARRIS

Authors
  1. MICHAEL R. BOYD
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  2. BENJAMIN J. WILSON
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  3. THOMAS M. HARRIS
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BOYD, M., WILSON, B. & HARRIS, T. Confirmation by Chemical Synthesis of the Structure of 4-Ipomeanol, a Lung-toxic Metabolite of the Sweet Potato, Ipomoea batatas. Nature New Biology 236, 158–159 (1972). https://doi.org/10.1038/newbio236158a0

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  • DOI: https://doi.org/10.1038/newbio236158a0

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