Abstract
THERE are two biochemical systems which probably evolved before the development of accurate polynucleotide-specified protein synthesis: these are the system for polynucleotide replication, and the machinery of protein synthesis itself1, 2. Before accurately specified proteins became available, these processes were perhaps catalysed by polynucleotide enzymes. Both tRNA and rRNA, which can be viewed as polynucleotide enzymes, have persisted as indispensable components of the contemporary apparatus. This has led me to wonder whether polynucleotide enzymes might still be operative in DNA replication. Moreover, in view of the complexity which would have been required for even a rudimentary form of protein synthesis, it seems unlikely that tRNA and rRNA arose by chance in a single evolutionary step1. More probably they have evolved from the replicative machinery for polynucleotides, and thus it seems likely that the machinery of DNA replication may have many features in common with the polynucleotide components of protein synthesis.
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BREWIN, N. Catalytic Role for RNA in DNA Replication. Nature New Biology 236, 101 (1972). https://doi.org/10.1038/newbio236101a0
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DOI: https://doi.org/10.1038/newbio236101a0
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