Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Effect of Prostaglandin E2 and Aspirin on the Secondary Aggregation of Human Platelets

Nature New Biology volume 236, pages 45–46 (1972)Cite this article

Abstract

THE lack of cellular specificity1 of the prostaglandins creates potential hazards in their use as therapeutic agents: we describe one associated with PGE2, and the reversal of the effect with aspirin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bergstrom, S., Carlson, L. A., and Weeks, J. R., Pharmacol. Rev., 20, 1 (1968).

    CAS  PubMed  Google Scholar 

  2. Kloeze, J., in Prostaglandins (edit. by. Bergstrom, S., and Samuelsson, B.), 241 (Almqvist and Wiksell, Stockholm, 1967).

    Google Scholar 

  3. Hissen, W., Fleming, J. S., Bierwagen, M. E., and Pindell, M. H., Microvasc. Res., 1, 374 (1969).

    Article  CAS  Google Scholar 

  4. Hornstra, G., Europ. J. Pharmacol., 15, 343 (1971).

    Article  CAS  Google Scholar 

  5. Marquis, N. R., Vigdahl, R. L., and Tavormina, P. A., Biochem. Biophys. Res. Commun., 36, 965 (1969).

    Article  CAS  Google Scholar 

  6. Robison, G. A., Arnold, A., and Hartman, R. C., Pharmacol. Res. Commun., 1, 325 (1969).

    Article  CAS  Google Scholar 

  7. Shio, H., Plasse, A. M., and Ramwell, P. W., Microvasc. Res., 2, 294 (1970).

    Article  CAS  Google Scholar 

  8. Born, G. V. R., Nature, 194, 927 (1962).

    Article  CAS  Google Scholar 

  9. Corey, E. J., Schaaf, T. K., Huber, W., Koelliker, U., and Weinshenker, N. M., J. Amer. Chem. Soc., 92, 397 (1970).

    Article  CAS  Google Scholar 

  10. McMillan, D. C., Nature, 211, 140 (1966).

    Article  Google Scholar 

  11. Zucker, M. B., and Peterson, J., Proc. Soc. Exp. Biol. Med., 127, 547 (1968).

    Article  CAS  Google Scholar 

  12. Sutor, A. H., Bowie, E. J. W., and Owen, C. A., Mayo Clin. Proc., 46, 178 (1971).

    CAS  PubMed  Google Scholar 

  13. van Creveld, S., and Pascha, C. N., Nature, 218, 361 (1968).

    Article  CAS  Google Scholar 

  14. Shio, H., and Ramwell, P. W., in Prostaglandins in Cellular Biology and the Inflammatory Process (edit. by Ramwell, P. W, and Pharriss, B. B. (Plenum, New York, in the press).

  15. Abdulla, Y. H., and McFarlane, E., Biochem. Pharmacol., 20, 1726 (1971).

    Article  CAS  Google Scholar 

  16. Smith, J. B., and Willis, A. L., Brit. J. Pharmacol., 40, 545P (1970).

    CAS  Google Scholar 

  17. Smith, J. B., and Willis, A. L., Nature New Biology, 231, 235 (1971).

    Article  CAS  Google Scholar 

  18. Willis, A. L., J. Pharm. Pharmacol., 21, 126 (1969).

    Article  CAS  Google Scholar 

  19. Marcus, A. J., Ullman, H. L., and Safier, L. B., J. Lipid Res., 10, 108 (1969).

    CAS  PubMed  Google Scholar 

  20. Embrey, M., Ann. NY Acad. Sci., 180, 518 (1971).

    Article  CAS  Google Scholar 

  21. Mustard, J. F., and Packham, M. A., in Inflammation, Immunity and Hypersensitivity (edit. by Movat, H. Z.), 527 (Harper and Row, New York, 1971).

    Google Scholar 

  22. Danta, G., Thromb. Diath. Haemorrh., 23, 159 (1970).

    Article  CAS  Google Scholar 

  23. Zahavi, J., and Dreyfuss, F., Thromb. Diath. Haemorrh., 21, 76 (1969).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biological Sciences, ALZA Corporation, Palo Alto, California, 94304

    HIDEO SHIO & PETER RAMWELL

Authors
  1. HIDEO SHIO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. PETER RAMWELL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SHIO, H., RAMWELL, P. Effect of Prostaglandin E2 and Aspirin on the Secondary Aggregation of Human Platelets. Nature New Biology 236, 45–46 (1972). https://doi.org/10.1038/newbio236045a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio236045a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing