Abstract
COOPER has summarized the recent evidence that the asymmetric labelling of 28S and 18S rRNA in non-growing human lymphocytes reflects the rapid turnover (“wastage”) of rRNA1. His summary has been presented in response to an alternative interpretation that such asymmetries reflect very long transcription times for the synthesis of rRNA precursor molecules2. I have examined in detail the experimental basis of each of these arguments and I still do not find the evidence for “wastage” in lymphocytes sufficiently conclusive to eliminate an extended transcription time interpretation. My views on each of his four points are summarized briefly.
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References
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EMERSON, C. Control of rRNA Production in Non-growing Cells. Nature New Biology 236, 32 (1972). https://doi.org/10.1038/newbio236032a0
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DOI: https://doi.org/10.1038/newbio236032a0
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