Abstract
THE possibility that nitrosamines, many of which are powerful carcinogens, can be formed in the stomach of mammals from ingested amines and nitrites1 has led to speculation on the sources of relevant amines for man2. One such source is the large number of drugs that are secondary or tertiary amines, many being taken by an individual for a long time.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sander, J., Arch. Hyg., 151, 22 (1967).
Lijinsky, W., and Epstein, S. S., Nature, 225, 21 (1970).
Sen, N. P., Smith, D. C., and Schwinghamer, L., Food Cosmet. Toxicol., 7, 301 (1969).
Sander, J., Schweinsberg, F., and Menz, H. P., Z. Physiol. Chem., 349, 1691 (1968).
Sander, J., and Bürkle, G., Z. Krebsforsch., 73, 54 (1969).
Greenblatt, M., Mirvish, S., and So, B. T., J. Nat. Cancer Inst., 46, 1029 (1971).
Smith, P. A. S., and Loeppky, R. N., J. Amer. Chem. Soc., 89, 1147 (1967).
Druckrey, H., Preussmann, R., Ivankovic, S., and Schmähl, D., Z. Krebsforsch., 69, 103 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GREENBLATT, M., KOMMINENI, V., CONRAD, E. et al. In vivo Conversion of Phenmetrazine into its N-Nitroso Derivative. Nature New Biology 236, 25–26 (1972). https://doi.org/10.1038/newbio236025a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio236025a0
This article is cited by
-
Studies of the tumorigenic effect in feeding of nitrosamino acids and of low doses of amines and nitrite to rats
Zeitschrift für Krebsforschung und Klinische Onkologie (1973)
-
Carcinogenic Nitrosamines formed by Drug/Nitrite Interactions
Nature (1972)