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Expression of a New Complement-fixing Antigen reactive with Murine Sarcoma Virus Rat Antiserum in Rat Cells transformed by Polyoma Virus

Nature New Biology volume 235, pages 188–190 (1972)Cite this article

Abstract

WE reported accelerated transformation by DNA viruses (SV40 and polyoma) in rat embryo (RE) cells chronically infected with a C-type RNA virus1,2. Recently we found in RE cells transformed by polyoma virus a new complement-fixing (CF) antigen detectable by rat antisera having broad reactivity with the various intraspecies and interspecies antigens of the RNA tumour viruses3–8; this antigen, however, was distinct from the murine intraspecies and interspecies group-specific (gs) antigens both immunologically and by virtue of other properties. It is also distinct from the polyoma virion (capsid) and tumour (“T”) antigens.

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Authors and Affiliations

  1. Microbiological Associates, Inc., National Institutes of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    JOHNG S. RHIM, C. R. LENGEL, H. Y. CHO, K. K. TAKEMOTO, H. C. TURNER, R. J. HUEBNER & R. V. GILDEN

  2. Flow Laboratories, Inc., Rockville, Maryland, 20852

    JOHNG S. RHIM, C. R. LENGEL, H. Y. CHO, K. K. TAKEMOTO, H. C. TURNER, R. J. HUEBNER & R. V. GILDEN

Authors
  1. JOHNG S. RHIM
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  2. C. R. LENGEL
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  3. H. Y. CHO
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  4. K. K. TAKEMOTO
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  5. H. C. TURNER
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  6. R. J. HUEBNER
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  7. R. V. GILDEN
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RHIM, J., LENGEL, C., CHO, H. et al. Expression of a New Complement-fixing Antigen reactive with Murine Sarcoma Virus Rat Antiserum in Rat Cells transformed by Polyoma Virus. Nature New Biology 235, 188–190 (1972). https://doi.org/10.1038/newbio235188a0

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  • DOI: https://doi.org/10.1038/newbio235188a0

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