Abstract
C-TYPE viruses have been established as the causal agents of leukaemia in murine and feline species and have been characterized1,2. C-type virus is also probably associated with fibrosarcoma in non-human primates3–6. To determine whether viruses with identical characteristics are associated with other neoplasms in simian species, we looked for C-type viruses in cases of leukaemia. A gibbon (Hylobates lar) with a disseminated tumour (later confirmed as lymphosarcoma) was made available to the Comparative Oncology Laboratory by Dr Malcolm Jones of the University of California, San Francisco Medical Center. The principal sites of involvement (lymph node, liver and bone marrow) were extensively overrun with massive neoplastic cells, which were predominantly prolymphocytic forms. Electron microscopy revealed C-type particles identical to those observed in vitro in sections from lymph nodes, liver, spleen and bone marrow.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The discovery of the first human retrovirus: HTLV-1 and HTLV-2
Retrovirology Open Access 02 March 2005
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Moloney, J. B., J. Nat. Cancer Inst., 24, 933 (1960).
Kawakami, T. G., Theilen, G. H., Dungworth, D. L., Munn, R. J., and Beall, S. G., Science, 158, 1049 (1967).
Kawakami, T. G., McKain, D., and Fielding, H., Fifth Intern. Symp. Compar. Leukemia Res., Padua, Italy, 32 (1971).
Theilen, G. H., Rabin, H., Gould, D., Fowler, M. E., Cooper, R. W., and Dungworth, D. L., Fifth Intern. Symp. Compar. Leukemia Res., Padua, Italy, 32 (1971).
Theilen, G. H., Gould, D., Fowler, M. E., and Dungworth, D. L., J. Nat. Cancer Inst., 47, 881 (1971).
Wolfe, L. G., Deinhardt, F., Theilen, G. H., Rabin, H., Kawakami, T., and Bustad, L. K., J. Nat. Cancer Inst., 47, 1115 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KAWAKAMI, T., HUFF, S., BUCKLEY, P. et al. C-Type Virus associated with Gibbon Lymphosarcoma. Nature New Biology 235, 170–171 (1972). https://doi.org/10.1038/newbio235170a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio235170a0
This article is cited by
-
A new look at the origins of gibbon ape leukemia virus
Virus Genes (2017)
-
The discovery of the first human retrovirus: HTLV-1 and HTLV-2
Retrovirology (2005)
-
History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2
Oncogene (2005)
-
Infection of human cells by an endogenous retrovirus of pigs
Nature Medicine (1997)
-
Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles
Immunogenetics (1992)