Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Mechanism of Kasugamycin Resistance in Escherichia coli

Nature New Biology volume 235, pages 6–9 (1972)Cite this article

Abstract

Strains of Escherichia coli are resistant to the antibiotic kasugamycin due to the partial non-methylation of 16S ribosomal RNA. An RNA methylase activity, absent from resistant strains, is shown here to methylate in vitro the 16S RNA of resistant as well as sensitive strains.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Helser, T. L., Davies, J. E., and Dahlberg, J. E., Nature New Biology, 233, 12 (1967).

    Article  Google Scholar 

  2. Young, D. V., and Srinivasan, P. R., Biochim. Biophys. Acta, 238, 447 (1971).

    Article  CAS  Google Scholar 

  3. Traub, P., and Nomura, M., J. Mol. Biol., 34, 575 (1968).

    Article  CAS  Google Scholar 

  4. Sanger, F., Brownlee, G. G., and Barsell, B. G., J. Mol. Biol., 13, 373 (1965).

    Article  CAS  Google Scholar 

  5. Brownlee, G. G., and Sanger, F., J. Mol. Biol., 23, 337 (1967).

    Article  CAS  Google Scholar 

  6. Beaud, G., and Hayes, D. H., Europ. J. Biochem., 20, 525 (1971).

    Article  CAS  Google Scholar 

  7. Kurland, C. G., in Methods in Enzymology (edit. by Moldave, K., and Grossman, L.), 20C, 379 (Academic Press, New York, 1971).

    Google Scholar 

  8. Hayes, F., Hayes, D., Fellner, P., and Ehresmann, C., Nature New Biology, 232, 54 (1971).

    Article  CAS  Google Scholar 

  9. Traub, P., and Nomura, M., Proc. US Nat. Acad. Sci., 59, 777 (1968).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin, Madison, 53706

    TERRY L. HELSER & JULIAN E. DAVIES

  2. Department of Physiological Chemistry, University of Wisconsin, Madison, 53706

    JAMES E. DAHLBERG

Authors
  1. TERRY L. HELSER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JULIAN E. DAVIES
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. JAMES E. DAHLBERG
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HELSER, T., DAVIES, J. & DAHLBERG, J. Mechanism of Kasugamycin Resistance in Escherichia coli. Nature New Biology 235, 6–9 (1972). https://doi.org/10.1038/newbio235006a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio235006a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing