Abstract
LITTLE is known about the mechanism by which antibodies are produced against foreign substances but not against components of the body. Mishell and Dutton1 developed a cell culture system for formation of antibody against sheep red blood cells (RBC) as antigen1. Mosier demonstrated that both macrophages and lymphocytes in mouse spleen are responsible for antibody formation2.
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MARUTA, H., MIZUNO, D. Selective Recognition of Various Erythrocytes in Endocytosis by Mouse Peritoneal Macrophages. Nature New Biology 234, 246–248 (1971). https://doi.org/10.1038/newbio234246a0
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DOI: https://doi.org/10.1038/newbio234246a0