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Previously Undescribed Fibrinolysis Inhibitor in Human Blood

Nature New Biology volume 234, pages 180–181 (1971)Cite this article

Abstract

HUMAN serum contains several protease inhibitors, one of which is identified as α1-globulin (α1-antitrypsin) and another as α2-macroglobulin. Serum also contains inhibitors against the activation of plasminogen, which may differ from the protease inhibitors. Thus, inhibition of plasminogen activation by urokinase is selectively increased during the last trimester of pregnancy1,2. Likewise, increased inhibition of streptokinase-activated human euglobulin or of a tissue plasminogen activator was noticed in some groups of patients with thrombotic disease3,4. This observation is of particular interest because the tissue activator, which is present in venous endothelium5, is believed to assist in the removal of fibrinous deposits caused by tissue injury6.

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Authors and Affiliations

  1. James F. Mitchell Foundation, Institute for Medical Research, Washington DC, 20015

    ANNEMARIE SIEGEL-RALSTON & T. ASTRUP

Authors
  1. ANNEMARIE SIEGEL-RALSTON
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  2. T. ASTRUP
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SIEGEL-RALSTON, A., ASTRUP, T. Previously Undescribed Fibrinolysis Inhibitor in Human Blood. Nature New Biology 234, 180–181 (1971). https://doi.org/10.1038/newbio234180a0

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