Abstract
SEVERAL investigators have demonstrated the principle of selective removal of a subpopulation of antigen sensitive cells required for a particular antibody response. For example, cells necessary for the antibody response to protein antigens can be specifically removed by passage through an antigen coated column1; cells necessary for the haemolytic plaque forming cell response to sheep erythrocytes can be removed by exposing them to concentrations of 3H-thymidine lethal for DNA synthesizing cells2; and cells necessary for the agglutinin response to flagellin can be removed by treating the population with radioactive flagellin so that the cells which bind the antigen are inactivated3. The cells which remain after these procedures have been shown to have a normal level of activity against non-cross-reacting antigens. These findings are regarded as evidence for heterogeneity in the whole population of antigen sensitive cells such that each cell can only respond to one antigen or to a restricted range of different antigens.
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FORD, W., ATKINS, R. Specific Unresponsiveness of Recirculating Lymphocytes after Exposure to Histocompatibility Antigen in F1 Hybrid Rats. Nature New Biology 234, 178–180 (1971). https://doi.org/10.1038/newbio234178a0
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DOI: https://doi.org/10.1038/newbio234178a0
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