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Neurohormones on Brain Adenyl Cyclase Activity in vivo

Nature New Biology volume 233, pages 280–281 (1971)Cite this article

Abstract

CYCLIC adenosine 3′,5′-monophosphate (cyclic AMP) has been suggested to be the receptor site for neurotransmitters as well as a second messenger which mediates the action of a variety of hormones and neurohormones in animals and human tissues. Cyclic AMP is derived from adenosine triphosphate (ATP) by the activity of adenyl cyclase and it is metabolized into adenosine monophosphate (AMP) by phosphodiesterase. Beta receptor and adenyl cyclase may be the same in the peripheral tissues1. In vitro activation of adenyl cyclase activity by various putative neurotransmitters such as noradrenaline (NA), 5-hydroxytryptamine (5-HT), acetylcholine (ACh) and histamine in preparations from brain homogenates and slices is well established2. The in vivo effect, however, of these neurohormones on adenyl cyclase has not been studied.

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Authors and Affiliations

  1. Drug Dependence Research Center, Mendocino State Hospital, Talmage, California, 95481

    W. S. CHOU, A. K. S. HO & H. H. LOH

  2. Department of Pharmacology, University of California Medical Center, San Francisco, California, 94122

    W. S. CHOU, A. K. S. HO & H. H. LOH

Authors
  1. W. S. CHOU
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  2. A. K. S. HO
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  3. H. H. LOH
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CHOU, W., HO, A. & LOH, H. Neurohormones on Brain Adenyl Cyclase Activity in vivo. Nature New Biology 233, 280–281 (1971). https://doi.org/10.1038/newbio233280a0

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