Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

New Indicator of Histocompatibility Differences in vitro

Nature New Biology volume 233, pages 174–176 (1971)Cite this article

Abstract

THE haemolytic plaque-forming cell (p.f.c.) response to sheep erythrocytes (SRBC) of cultures containing spleen cells from two different strains of mouse may be depressed if the mice differ sufficiently at the H-2 locus1. In our system, however, the usual result is stimulation rather than depression. We present evidence that such stimulation does not result, as has been suggested2,3, from synergism between two cell populations, but from an immune reaction based on histocompatibility differences between them. The system provides a sensitive indicator for detecting and assessing immune reactions between histoincompatible lymphoid cells and mitogenic factors released by such reactions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hirano, S., and Uyeki, E. M., J. Immunol., 106, 619 (1971).

    CAS  PubMed  Google Scholar 

  2. Kennedy, J. C., Fed. Proc., 19, 240 (1970).

    Google Scholar 

  3. Goldie, J. H., and Osoba, D., Proc. Soc. Exp. Biol. Med., 133, 1265 (1970).

    Article  CAS  PubMed  Google Scholar 

  4. Marbrook, J., Lancet, ii, 1279 (1967).

    Article  Google Scholar 

  5. Cunningham, A., and Szenberg, A., Immunology, 14, 599 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Adler, W. H., Takiguchi, T., Marsh, B., and Smith, R. T., J. Immunol., 105, 984 (1970).

    CAS  PubMed  Google Scholar 

  7. Raff, M. C., Nature, 224, 378 (1970).

    Article  Google Scholar 

  8. Kettman, J., and Dutton, R. W., Proc. US Nat. Acad. Sci., 68, 699 (1971).

    Article  CAS  Google Scholar 

  9. Katz, D. H., Paul, W. E., Goidl, E. A., and Benacerraf, B., J. Exp. Med., 133, 169 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Tubergen, D. G., and Feldman, J. D., Fed. Proc., 30, 1873 (1971).

    Google Scholar 

  11. Weber, W. T., Clin. Exp. Immunol., 6, 919 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Hardy, D. A., and Ling, N. R., Nature, 221, 545 (1969).

    Article  CAS  PubMed  Google Scholar 

  13. Santos, G. W., J. Immunol, 97, 587 (1966).

    CAS  PubMed  Google Scholar 

  14. Haskill, J. S., Marbrook, J., and Elliott, B. E., Nature (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Queen's University, and Kingston General Hospital, Kingston, Ontario

    A. EKPAHA-MENSAH & J. C. KENNEDY

Authors
  1. A. EKPAHA-MENSAH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. KENNEDY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

EKPAHA-MENSAH, A., KENNEDY, J. New Indicator of Histocompatibility Differences in vitro. Nature New Biology 233, 174–176 (1971). https://doi.org/10.1038/newbio233174a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio233174a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing