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Hormone-activated Expression of the C-type RNA Tumour Virus Genome

Nature New Biology volume 233, pages 142–144 (1971)Cite this article

Abstract

THE concept of vertical transmission of specific viral information, particularly that possibly associated with the induction of malignancy in mice has been postulated. Moreover, it has been hypothesized that this genetic information may be expressed either in the form of whole virus in certain selected laboratory animal strains or as the operon involved in regulating cellular replication (oncogene)1. To detect this proposed genetically transmitted message, one uses a group specific antisera against the C-type RNA tumour viruses having as one of its components, gs-3, first described by Gerring et al.2. A similar group specific antigen has subsequently been reported by Schafer3, Gilden4 and Sarma et al.5, and designated “interspec”, meaning that the antigen is common to the internal components of the C-type RNA virion of several mammalian species.

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References

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Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    A. HELLMAN & A. K. FOWLER

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  1. A. HELLMAN
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  2. A. K. FOWLER
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HELLMAN, A., FOWLER, A. Hormone-activated Expression of the C-type RNA Tumour Virus Genome. Nature New Biology 233, 142–144 (1971). https://doi.org/10.1038/newbio233142a0

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