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Morphine and Nalorphine impair Neuromuscular Transmission

Nature New Biology volume 231, pages 94–96 (1971)Cite this article

Abstract

THE narcotic analgesic morphine and the analgesic-antagonist nalorphine both depress the twitch and tetanus of the coaxially stimulated guinea-pig ileum1. There is general agreement that morphine impairs the release of acetylcholine at this peripheral muscarinic site1–4. Less is agreed about the effects of morphine at nicotinic sites1,5–7. Because there is no evidence that the mechanisms of transmitter release differ fundamentally between muscarinic and nicotinic sites, we have examined the effects of morphine and nalorphine on some isolated skeletal neuromuscular preparations. A preliminary account of a portion of this work has already been reported8.

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References

  1. Paton, W. D. M., Brit. J. Pharmacol., 12, 119 (1957).

    CAS  PubMed  Google Scholar 

  2. Schaumann, W., Brit. J. Pharmacol., 12, 115 (1957).

    CAS  PubMed  Google Scholar 

  3. Cox, B. M., and Weinstock, M., Brit. J. Pharmacol. Chemother., 27, 81 (1966).

    Article  CAS  Google Scholar 

  4. Gyang, E. A., and Kosterlitz, H. W., Brit. J. Pharmacol. Chemother., 27, 514 (1966).

    Article  CAS  Google Scholar 

  5. Pelikan, E. W., Ann. NY Acad. Sci., 90, 52 (1960).

    Article  CAS  Google Scholar 

  6. Kosterlitz, H. W., Lees, G. M., and Watt, A. J., Pharmacol. Res. Commun., 1, 1 (1969).

    Article  Google Scholar 

  7. Hale, W., Amer. J. Physiol., 23, 408 (1909).

    Article  Google Scholar 

  8. Frederickson, R. C. A., and Pinsky, C., Fed. Proc., 29, 279 Abs. (1970).

    Google Scholar 

  9. Hebb, C. O., and Konzett, H., Nature, 163, 721 (1949).

    Article  Google Scholar 

  10. Frederickson, R. C. A., and Pinsky, C., Nature New Biology, 231, 93 (1971).

    Article  CAS  Google Scholar 

  11. Bulbring, E., Brit. J. Pharmacol., 1, 38 (1946).

    CAS  PubMed  Google Scholar 

  12. Krebs, H. A., and Henseleit, K., Z. Physiol. Chem., 210, 33 (1932).

    Article  CAS  Google Scholar 

  13. Dewey, W. L., Harris, L. S., et al., Arch. Intern. Pharmacodyn., 182, 471 (1969).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, 3

    C. PINSKY & R. C. A. FREDERICKSON

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  1. C. PINSKY
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  2. R. C. A. FREDERICKSON
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PINSKY, C., FREDERICKSON, R. Morphine and Nalorphine impair Neuromuscular Transmission. Nature New Biology 231, 94–96 (1971). https://doi.org/10.1038/newbio231094a0

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