Abstract
FELINE sarcoma virus (FSV) transforms human embryo cells in vitro1; it therefore seemed interesting to determine whether this virus could transform human osteosarcoma cells. Defective Moloney sarcoma virus genome can be rescued from non-producer hamster tumour cells by feline leukaemia virus (FeLV)2, and because FSV stocks also contain excess FeLV (ref. 1 and unpublished observations of R. V. G.), it was hoped that human osteosarcoma cells transformed by FSV and co-infected with FeLV might yield a human sarcoma virus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sarma, P. S., Huebner, R. J., Basker, J. F., Vernon, L., and Gilden, R. V., Science, 168, 1098 (1970).
Sarma, P. S., Log, T., and Huebner, R. J., Proc. US Nat. Acad. Sci., 65, 81 (1970).
McAllister, R. M., Gardner, M. B., Greene, A. E., Bradt, C., Nichols, W., and Landing, B. H., Cancer (in the press).
Moloney, J. B., J. Nat. Cancer Inst., 16, 877 (1966).
Gardner, M. B., Arnstein, P., Rongey, R. W., Estes, J. D., Sarma, P. S., Rickard, C. G., and Huebner, R. J., Nature, 226, 807 (1970).
Hartley, J. W., and Rowe, W. P., Proc. US Nat. Acad. Sci., 55, 780 (1960).
Macpherson, I., and Montagnier, L., Virology, 23, 291 (1964).
Robinson, H. L., Proc. US Nat. Acad. Sci., 57, 1655 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MCALLISTER, R., FILBERT, J., NICOLSON, M. et al. Transformation and Productive Infection of Human Osteosarcoma Cells by a Feline Sarcoma Virus. Nature New Biology 230, 279–282 (1971). https://doi.org/10.1038/newbio230279a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio230279a0
This article is cited by
-
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins
Oncogene (2000)
-
Transformation of human cells in culture by N-methyl-N′-nitro-N-nitrosoguanidine
Nature (1975)
-
RD-114 Virus compared with Feline and Murine Type-C Viruses released from RD Cells
Nature New Biology (1973)