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Isolation of C Reactive Protein and its Effect on Human Lymphocytes in vitro

Nature New Biology volume 230, pages 84–85 (1971)Cite this article

Abstract

C REACTIVE protein (CRP) appears in the serum of human and other animal species during acute inflammation. Its amount is related to the severity of inflammatory response, irrespective of its cause. CRP is probably made by normal cells1 and then released locally at the time of injury2. It is not made de novo by injured cells3. Its reaction with C polysaccharide requires divalent cations and is related to the polyanionic nature of this highly phosphorylated carbohydrate4. The kinetics of the reaction are similar to antigen-antibody reactions but CRP is not an immunoglobulin5. Its function is unknown.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Tulane University Medical School, New Orleans, Louisiana

    MARIA HORNUNG & SUSAN FRITCHI

Authors
  1. MARIA HORNUNG
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  2. SUSAN FRITCHI
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HORNUNG, M., FRITCHI, S. Isolation of C Reactive Protein and its Effect on Human Lymphocytes in vitro. Nature New Biology 230, 84–85 (1971). https://doi.org/10.1038/newbio230084a0

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  • DOI: https://doi.org/10.1038/newbio230084a0

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