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Increased Transformation Efficiency of Simian Virus 40 in Rat Embryo Cells infected with Rauscher Leukaemia Virus

Nature New Biology volume 230, pages 81–83 (1971)Cite this article

Abstract

SIMIAN virus 40 (SV40) is oncogenic for hamsters1 and Mastomys2. In vitro studies have shown that SV40 is capable of transforming cells derived from hamster3, mouse4, rabbit4, pig4, cow5, monkey6, human7, guinea-pig8 and rat9. We have established and studied continuous lines of uninfected and Rauscher leukaemia virus (RLV) infected rat embryo (RE) cells10. Rat embryo cells exposed to RLV have produced infectious virus and complement-fixing (CF) antigen characteristic of the murine leukaemia-sarcoma virus complex for more than 18 months. This communication describes increased transformation efficiency of SV40 in RLV infected RE cells (RLV-RE) compared with uninfected RE cells.

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Authors and Affiliations

  1. Department of Virus Research, Microbiological Associates, Inc., and National Institutes of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    JOHNG S. RHIM, CHARLOTTE GREENAWALT, K. K. TAKEMOTO & R. J. HUEBNER

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  1. JOHNG S. RHIM
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  2. CHARLOTTE GREENAWALT
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  4. R. J. HUEBNER
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RHIM, J., GREENAWALT, C., TAKEMOTO, K. et al. Increased Transformation Efficiency of Simian Virus 40 in Rat Embryo Cells infected with Rauscher Leukaemia Virus. Nature New Biology 230, 81–83 (1971). https://doi.org/10.1038/newbio230081a0

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