Abstract
Chloramphenicol stabilizes pre-existing lac mRNA, but inhibits further accumulation by allowing rapid degradation of nascent message. Puromycin accelerates decay of pre-existing and new lac message by discharging protective ribo-somes. Both effects are partially reversed by the suA mutation.
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VARMUS, H., PERLMAN, R. & PASTAN, I. Regulation of lac Transcription in Antibiotic-treated E. coli. Nature New Biology 230, 41–44 (1971). https://doi.org/10.1038/newbio230041a0
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DOI: https://doi.org/10.1038/newbio230041a0
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