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Isolation and Characterization of Antigenic Components of a New Heptavalent Pseudomonas Vaccine

Nature New Biology volume 229, pages 209–210 (1971)Cite this article

Abstract

ONE of the most serious opportunistic bacterial pathogens is Pseudomonas aeruginosa1, and the inability of the common antimicrobial agents to combat such infections suggested the investigation of specific immunological prophylactic and therapeutic approaches. Therefore Fisher et al. began to develop a new serotype schema as a prerequisite for an immunizing preparation which would protect humans against the most prevalent strains of Pseudomonas. This communication describes the isolation, purification and preliminary characterization of seven new lipopolysaccharide antigens which were obtained from strains representative of each of the seven protective serotypes identified by Fisher et al.2.

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References

  1. Brit. Med. J., 1019 (1964).

  2. Fisher, M. W., Devlin, H. B., and Gnabasik, F. J., J. Bact., 98, 835 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Sawardeker, J. S., Sloneker, J. H., and Jeanes, A., Anal. Chem., 37, 1602 (1965).

    Article  CAS  Google Scholar 

  4. Burton, A. J., and Carter, H. E., Biochemistry, 3, 411 (1964).

    Article  CAS  PubMed  Google Scholar 

  5. Hodge, J. E., and Hofreiter, B. T., in Methods in Carbohydrate Chemistry, 1, 388 (Academic Press, New York, 1963).

    Google Scholar 

  6. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  7. Weissbach, A., and Hurwitz, J., J. Biol. Chem., 234, 705 (1959).

    CAS  PubMed  Google Scholar 

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Author notes

  1. STEPHEN HANESSIAN

    Present address: Department of Chemistry, University of Montreal, Montreal, Quebec, Canada

Authors and Affiliations

  1. Parke-Davis and Co., Ann Arbor, Michigan, 48106

    STEPHEN HANESSIAN, WILLIAM REGAN, DONALD WATSON & THEODORE H. HASKELL

Authors
  1. STEPHEN HANESSIAN
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  2. WILLIAM REGAN
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  3. DONALD WATSON
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  4. THEODORE H. HASKELL
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HANESSIAN, S., REGAN, W., WATSON, D. et al. Isolation and Characterization of Antigenic Components of a New Heptavalent Pseudomonas Vaccine. Nature New Biology 229, 209–210 (1971). https://doi.org/10.1038/newbio229209a0

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  • DOI: https://doi.org/10.1038/newbio229209a0

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