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New Fibrous Long Spacing Form of Collagen

Nature New Biology volume 229, pages 151–152 (1971)Cite this article

Abstract

PRECIPITATION of collagen from solution in the presence of chondroitin sulphates (or certain other glycosaminoglycans), followed by dialysis against water, leads to the formation of the fibrous long spacing (FLS) polymorphic form of collagen. Electron microscopy shows this to consist of banded fibrils with a periodicity in the range 1200–2400 Å and a symmetric intraperiod structure, in contrast to the 600–700 Å periodicity and polarized fine structure characteristic of native collagen fibrils. FLS was originally reported by Highberger et al.1–3 and has been observed in three principal modifications, FLS I, FLS II and FLS III, differing in periodicity and arrangement of dense bands4–6. This letter reports a new form of FLS, denoted FLS IV.

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References

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Author notes

  1. PHYLLIS M. ARMITAGE

    Present address: ARC Unit of Muscle Mechanisms and Insect Physiology, Department of Zoology, University of Oxford,

Authors and Affiliations

  1. Rheumatism Research Centre, University of Manchester, M13 0JJ

    PHYLLIS M. ARMITAGE & JOHN A. CHAPMAN

Authors
  1. PHYLLIS M. ARMITAGE
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  2. JOHN A. CHAPMAN
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ARMITAGE, P., CHAPMAN, J. New Fibrous Long Spacing Form of Collagen. Nature New Biology 229, 151–152 (1971). https://doi.org/10.1038/newbio229151a0

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