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Polymorphic Alleles of the Gene for the β Chain of Rabbit Haemoglobin

Nature New Biology volume 229, pages 142–143 (1971)Cite this article

Abstract

THE primary structure of the haemoglobin chains from individuals of many species is not unique. The α chain of rabbit haemoglobin has six positions at which more than one amino-acid occurs1. Such amino-acid multiplicities have also been found for the α chain of mouse2,3, goat4 and horse5 haemoglobin and for the γ chain of human haemoglobin6. In some cases a simple mechanism can be put forward to explain the variability, as for the human γ chain6 and the mouse α chain3, where the presence of tandem genes seems to be established. Three of the variable positions of the α chain of rabbit haemoglobin can be explained as resulting from polymorphic alleles of a single α chain gene7.

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References

  1. Von Ehrenstein, G., Cold Spring Harbor Symp. Quant. Biol., 31, 705 (1966).

    Article  CAS  Google Scholar 

  2. Rifkin, D. B., Rifkin, M. R., and Konigsberg, W., Proc. US Nat. Acad. Sci., 55, 586 (1966).

    Article  CAS  Google Scholar 

  3. Hilse, K., and Popp, R. A., Proc. US Nat. Acad. Sci., 61, 930 (1968).

    Article  CAS  Google Scholar 

  4. Huisman, T. H. J., Brandt, G., and Wilson, J. B., J. Biol. Chem., 342, 3675 (1968).

    Google Scholar 

  5. Kilmartin, J. V., and Clegg, J. B., Nature, 213, 269 (1967).

    Article  CAS  Google Scholar 

  6. Schroeder, W. A., Huisman, T. H. J., Shelton, J. R., Shelton, J. B., Kleihauer, E. F., Dozy, A. M., and Robberson, B., Proc. US Nat. Acad. Sci., 60, 537 (1968).

    Article  CAS  Google Scholar 

  7. Hunter, T., and Munro, A., Nature, 223, 1270 (1969).

    Article  CAS  Google Scholar 

  8. Galizzi, A., Europ. J. Biochem. (in the press).

  9. Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966).

    Article  CAS  Google Scholar 

  10. Braunitzer, G., Best, J. S., Framm, V., and Schrank, B., Z. Physiol. Chem., 347, 207 (1966).

    Article  CAS  Google Scholar 

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Author notes

  1. ALESSANDRO GALIZZI

    Present address: Istituto di Genetica, Università di Pavia, 27100, Pavia

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  1. Department of Biophysics, The Johns Hopkins University School of Medicine, Baltimore, Maryland

    ALESSANDRO GALIZZI

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  1. ALESSANDRO GALIZZI
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GALIZZI, A. Polymorphic Alleles of the Gene for the β Chain of Rabbit Haemoglobin. Nature New Biology 229, 142–143 (1971). https://doi.org/10.1038/newbio229142a0

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  • DOI: https://doi.org/10.1038/newbio229142a0

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