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Effects of Cytochalasin B on Muscle Cells in Tissue Culture

Nature New Biology volume 229, pages 121–123 (1971)Cite this article

An Erratum to this article was published on 17 March 1971

Abstract

THE antibiotic cytochalasin B induces the formation of binucleated and multinucleated cells by preventing cytokinesis1, and the cleavage furrow filaments in sea urchin eggs, 50-100 Å in diameter, disappear in the presence of this compound2. It has a similar effect on the fine filaments found in embryonic pancreatic cells3, and inhibits cell migration1. Many kinds of cells displaying amoeboid movements have been reported to have 50-100 Å filaments4–6. Ishikawa et al. have demonstrated that 60–80 Å filaments in the cortex of various tissue cells bind heavy-meromyosin in a manner identical to that of actin filaments, which are also 60–80 Å in diameter7. Many investigators have referred to these thin filaments as actin or actin-like and assumed them to be responsible for, or associated with, cellular movements8,9, contraction10,11, and cytokinesis12,13.

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Author notes

  1. S. HOLTZER and H. HOLTZER: On leave from the University of Pennsylvania, Philadelphia.

Authors and Affiliations

  1. Department of Anatomy School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

    J. W. SANGER

  2. Medical Research Council, Laboratory of Molecular Biology, Cambridge

    J. W. SANGER

  3. Medical Research Council, Laboratory of Molecular Biology, Cambridge

    S. HOLTZER & H. HOLTZER

Authors
  1. J. W. SANGER
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  2. S. HOLTZER
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  3. H. HOLTZER
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SANGER, J., HOLTZER, S. & HOLTZER, H. Effects of Cytochalasin B on Muscle Cells in Tissue Culture. Nature New Biology 229, 121–123 (1971). https://doi.org/10.1038/newbio229121a0

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