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Location of the Glycoprotein in the Membrane of Sindbis Virus

Nature New Biology volume 229, pages 114–116 (1971)Cite this article

Abstract

SINDBIS virus, which is transmitted by arthropods, consists of a nucleoprotein core within a lipid-containing envelope. Its components assemble at a cellular membrane, and virus particles form by an outfolding of this membrane. Thus, such viruses provide useful systems for studies of the structure and synthesis of membranes. The Sindbis virus particle contains only two proteins, one associated with the viral envelope and the other with the viral RNA in the core, or nucleocapsid1. The protein associated with the membrane is a glycoprotein, whereas the core protein contains no carbohydrate2. The exact location of the glycoprotein within the viral envelope has not been determined, nor has information been obtained about the function of the carbohydrate in the virion. The results described here indicate that the spikes which cover the surface of the virion are glycoprotein in nature.

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  1. The Rockefeller University, New York, New York, 10021

    RICHARD W. COMPANS

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  1. RICHARD W. COMPANS
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COMPANS, R. Location of the Glycoprotein in the Membrane of Sindbis Virus. Nature New Biology 229, 114–116 (1971). https://doi.org/10.1038/newbio229114a0

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