Abstract
RNA viruses of several animal leukaemias and sarcomas possess what seems so far to be a unique enzyme—an RNA dependent DNA polymerase1–6. Specific inhibitors of the viral enzyme will not only be useful in the analysis of its possible role in neoplasia, but might provide drugs for leukaemia and cancer therapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Baltimore, D., Nature, 226, 1209 (1970).
Green, M., Rokutanda, M., Fujinaga, K., Ray, R. K., Rokutanda, H., and Gurgo, C., Proc. US Nat. Acad. Sci., 67, 385 (1970).
Rokutanda, M., Rokutanda, H., Green, M., Fujinaga, K., Ray, R. K., and Gurgo, C., Nature, 227, 1026 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Hatanaka, M., Huebner, R. J., and Gilden, R. V., Proc. US Nat. Acad. Sci., 67, 143 (1970).
Ben-Ishai, Z., Heller, E., Goldblum, N., and Becker, Y., Nature, 224, 29 (1969).
Heller, E., Argaman, M., Levy, H., and Goldblum, N., Nature, 222, 273 (1969).
McAuslan, B. R., Biochem. Biophys. Res. Commun., 37, 289 (1969).
Moss, B., Rosenblum, E. N., Katz, E., and Grimley, P. M., Nature, 224, 1280 (1969).
Subak-Sharpe, J. H., Timbury, M. C., and Williams, J. F., Nature, 222, 341 (1969).
Zakay-Rones, Z., and Becker, Y., Nature, 226, 1162 (1970).
Nagayama, A., Pogo, B. G. T., and Dales, S., Virology, 40, 1039 (1970).
Diggelmann, H., and Weissmann, C., Nature, 224, 1277 (1969).
Katz, E., and Moss, B., Proc. US Nat. Acad. Sci., 66, 677 (1970).
Green, M., Pina, M., and Chagoya, V., J. Biol. Chem., 239, 1188 (1964).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 1029 (1970).
Mizutani, S., and Temin, H. M., Nature (in the press).
Fujinaga, K., Parsons, J. T., Beard, J. W., Beard, D., and Green, M., Proc. US Nat. Acad. Sci. (in the press).
Haselkorn, R., Science, 143, 682 (1964).
Richardson, C. C., Procedures in Nucleic Acid Research, 263 (Harper and Row, New York, 1966).
di Mauro, E., Snyder, L., Marino, P., Lamberti, A., Coppo, A., and Tocchini-Valentini, G. P., Nature, 222, 533 (1969).
Sippel, A., and Hartmann, G., Biochim. Biophys. Acta, 157, 218 (1968).
Geiduschek, E. P., and Sklar, J., Nature, 111, 833 (1969).
Haselkorn, R., Vogel, M., and Brown, R. D., Nature, 211, 836 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GURGO, C., RAY, R., THIRY, L. et al. Inhibitors of the RNA and DNA Dependent Polymerase Activities of RNA Tumour Viruses. Nature New Biology 229, 111–114 (1971). https://doi.org/10.1038/newbio229111a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio229111a0
This article is cited by
-
Carcinogenesis
Die Naturwissenschaften (1975)
-
Hemmung der viralen Reverse-Transcriptase und Leuk�mogenese mit modifizierten Nucleins�uren
Zeitschrift f�r Krebsforschung und Klinische Onkologie (1975)
-
Is Gene Amplification RNA-directed?
Nature New Biology (1973)
-
Molekulare Grundlagen viral bedingter Tumoren
Klinische Wochenschrift (1973)
-
Inhibitory effect of streptonigrin on a murine sarcoma virus-induced tumor cell line (MSC) and selection of drug-resistant clones
In Vitro (1973)