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Metastatic colorectal cancer: irinotecan plus infusional, bolus or oral fluoropyrimidines as first-line treatment

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  1. 1

    Douillard JY et al. (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355: 1041–1047

    CAS  Article  Google Scholar 

  2. 2

    de Gramont A et al. (1997) Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J Clin Oncol 15: 808–815

    CAS  Article  Google Scholar 

  3. 3

    Colucci G et al. (2005) Phase III randomized trial of FOLFIRI versus FOLFOX 4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. J Clin Oncol 23: 4866–4875

    CAS  Article  Google Scholar 

  4. 4

    Rea DW et al. (2005) A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer. Ann Oncol 16: 1123–1132

    CAS  Article  Google Scholar 

  5. 5

    Koopman M et al. (2007) Sequential versus combination chemotherapy with capecitabine, irinotecan and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet 370: 135–142

    CAS  Article  Google Scholar 

  6. 6

    Midgley RM and Kerr DJ (2008) Capecitabine: have we got the dose right? Nat Clin Pract Oncol (in press)

    Google Scholar 

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The synopsis was written by Mandy Aujla, Associate Editor, Nature Clinical Practice.

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D Kerr is a speaker and receives grant/research support from Roche.

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Kerr, D. Metastatic colorectal cancer: irinotecan plus infusional, bolus or oral fluoropyrimidines as first-line treatment. Nat Rev Clin Oncol 5, 250–251 (2008).

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