Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Study
  • Published:

Recurrent endometrial stromal tumors with smooth-muscle differentiation and a protracted clinical course

Nature Clinical Practice Oncology volume 2, pages 588–593 (2005)Cite this article

Abstract

Background A 24-year-old white female gravida 1, para 0010, presented with heavy vaginal bleeding and abdominal cramps of 2 weeks' duration. Medical history was remarkable for spontaneous abortion 5 years previously. She had no significant family history or other gynecological problems. Physical examination revealed tissue fragments and blood clots oozing from the cervical os, and her uterus was diffusely enlarged.

Investigations Physical examination, ultrasound, uterine dilation and curettage, immunohistochemistry and human androgen receptor gene clonality analysis, uterine sonohistogram, MRI and exploratory laparotomy.

Diagnosis Intrauterine dissemination of endometrial stromal tumors with smooth-muscle differentiation.

Management Partial wedge resection of the anterior uterine wall via abdominal myomectomy and total abdominal hysterectomy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Gross pathological findings of the uterus.
Figure 2: Microscope features and human androgen receptor gene clonality analysis of representative lesions.

References

  1. Olive E et al. (1998) Mixed endometrial stromal and smooth muscle tumors of the uterus—a clinicopathologic study of 15 cases. Am J Surg Pathol 22: 997–1005

    Article  Google Scholar 

  2. Tavassoli FA et al. (1981) Mesenchymal tumours of the uterus. VII. A clinicopathological study of 60 endometrial stromal nodules. Histopathology 5: 1–10

    Article  CAS  Google Scholar 

  3. Yilmaz A et al. (2002) Endometrial stromal sarcomas with unusual histologic features: a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation. Am J Surg Pathol 26:1142–1150

    Article  Google Scholar 

  4. Piver MS et al. (1984) Endolymphatic stromal myosis: a collaborative study. Obstet Gynecol 64: 173–178

    Article  CAS  Google Scholar 

  5. Sutton GP et al. (1986). Estrogen and progesterone receptors in uterine sarcoms. Obstet Gynecol 68: 709–714

    CAS  PubMed  Google Scholar 

  6. Leiser AL et al. (2004) Recurrence of prolactin-producing endometrial stromal sarcoma with sex-cord stromal component treated with progestin and aromatase inhibitor. Gynecol Oncol 94: 567–571

    Article  CAS  Google Scholar 

  7. Schilder JM et al. (1999) Hormonal treatment of an endometrial stromal nodule followed by local excision. Obstet Gynecol 93: 805–807

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yale–New Haven Hospital, New Haven, CT, USA

    Pei Hui & George Fedoriw

  2. Associate Member of Yale Cancer Center,

    Pei Hui & George Fedoriw

  3. Medical Director of Molecular Diagnostic Laboratory at Yale Pathology Department,

    Pei Hui & George Fedoriw

  4. Yale–New Haven Hospital,

    Pei Hui & George Fedoriw

Authors
  1. Pei Hui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Fedoriw
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pei Hui.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hui, P., Fedoriw, G. Recurrent endometrial stromal tumors with smooth-muscle differentiation and a protracted clinical course. Nat Rev Clin Oncol 2, 588–593 (2005). https://doi.org/10.1038/ncponc0340

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc0340

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing