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Increased lesion load and atrophy of white and gray matter in multiple sclerosis patients

Nature Clinical Practice Neurology volume 1, pages 8–9 (2005)Cite this article

Tedeschi G et al. (2005) Brain atrophy and lesion load in a large population of patients with multiple sclerosis. Neurology 65: 280–285

The relationship between the level and location of brain atrophy and the clinical manifestations of multiple sclerosis (MS) remains to be clarified. Variations in MRI techniques and failure to measure all significant variables have made interpretation of results from previous studies difficult. Researchers from Italy have now used a fully automated MRI technique to compare volumes of white matter (WM) and gray matter (GM), as well as lesion load, in a large cohort of patients with MS and a group of healthy volunteers.

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  1. Pippa Murdie
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Murdie, P. Increased lesion load and atrophy of white and gray matter in multiple sclerosis patients. Nat Rev Neurol 1, 8–9 (2005). https://doi.org/10.1038/ncpneuro0009

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