The sheer quantity and complexity of gene expression data can provide extraordinarily accurate descriptions of differences between states of cells, tissues and whole organisms. A compendium of genomic signatures that attempts to describe all biological states has the potential to reveal hidden connections among drugs, genes and diseases.
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References
Chee, M. et al. Science 274, 610–614 (1996).
Marton, M.J. et al. Nat. Med. 4, 1293–1301 (1998).
Hardwick, J.S., Kuruvilla, F.G., Tong, J.K., Shamji, A.F. & Schreiber, S.L. Proc. Natl. Acad. Sci. USA 96, 14866–14870 (1999).
Hughes, T.R. et al. Cell 102, 109–126 (2000).
Stoughton, R.B. & Friend, S.H. Nat. Rev. Drug Discov. 4, 345–350 (2005).
Lamb, J. et al. Science 313, 1929–1935 (2006).
Ramaswamy, S., Ross, K.N., Lander, E.S. & Golub, T.R. Nat. Genet. 33, 49–54 (2003).
Macdonald, M.L. et al. Nat. Chem. Biol. 2, 329–337 (2006).
Giaever, G. et al. Proc. Natl. Acad. Sci. USA 101, 793–798 (2004).
Lum, P.Y. et al. Cell 116, 121–137 (2004).
Parsons, A.B. et al. Nat. Biotechnol. 22, 62–69 (2004).
Parsons, A.B. et al. Cell 126, 611–625 (2006).
Perlman, Z.E. et al. Science 306, 1194–1198 (2004).
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Michnick, S. The connectivity map. Nat Chem Biol 2, 663–664 (2006). https://doi.org/10.1038/nchembio1206-663
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DOI: https://doi.org/10.1038/nchembio1206-663