Ascidians obtain diverse libraries of cytotoxic compounds by maintaining cyanobacterial symbionts that have combinatorial variants of a natural-product pathway. The biosynthetic flexibility of this route can be used to genetically engineer new substances.
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References
Newman, D.J. & Cragg, G.M. J. Nat. Prod. 67, 1216–1238 (2004).
Piel, J. et al. Proc. Natl. Acad. Sci. USA 101, 16222–16227 (2004).
Schmidt, E.W. et al. Proc. Natl. Acad. Sci. USA 102, 7315–7320 (2005).
Long, P.F., Dunlap, W.C., Battershill, C.N. & Jaspars, M. ChemBioChem 6, 1760–1765 (2005).
Donia, M.S. et al. Nat. Chem. Biol. 2, 729–735 (2006).
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Piel, J. Combinatorial biosynthesis in symbiotic bacteria. Nat Chem Biol 2, 661–662 (2006). https://doi.org/10.1038/nchembio1206-661
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DOI: https://doi.org/10.1038/nchembio1206-661
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