The emergence of a primordial RNA world would have required the formation of RNA polymers of sufficient length to possess catalytic activities, which are difficult to obtain by spontaneous polymerization. An analysis of an autocatalytic assembly pathway that can self-construct a functioning ribozyme from smaller oligonucleotide building blocks describes a potential route for RNA extension.
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References
Gilbert, W. Nature 319, 618 (1986).
Nissen, P. et al. Science 289, 920–930 (2000).
Cech, T.R. Biosci. Rep. 10, 239–261 (1990).
Chen, X., Li, N. & Ellington, A.D. Chem. Biodivers. 4, 633–655 (2007).
Hayden, E.J., von Kiedrowski, G. & Lehman, N. Angew. Chem. Int. Ed. Engl. published online, doi:10.1002/anie.200802177 (9 September 2008).
Ferris, J.P., Hill, A.R. Jr., Liu, R. & Orgel, L.E. Nature 381, 59–61 (1996).
Doudna, J.A., Couture, S. & Szostak, J.W. Science 251, 1605–1608 (1991).
Hayden, E.J. & Lehman, N. Chem. Biol. 13, 909–918 (2006).
Eigen, M. Naturwissenschaften 58, 465–523 (1971).
Ludlow, R.F. & Otto, S. Chem. Soc. Rev. 37, 101–108 (2008).
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Seelig, B. An autocatalytic network for ribozyme self-construction. Nat Chem Biol 4, 654–655 (2008). https://doi.org/10.1038/nchembio1108-654
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DOI: https://doi.org/10.1038/nchembio1108-654
