Nitric oxide–mediated production of cyclic guanosine 3′,5′-monophosphate (cGMP) is a crucial signal transduction pathway that controls a wide array of biological functions. A new layer of complexity in mammalian cell regulation is revealed by the discovery of a redox-active nitrated cGMP derivative with the ability to post-translationally modify protein thiol residues by S-guanylation.
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Feelisch, M. Nitrated cyclic GMP as a new cellular signal. Nat Chem Biol 3, 687–688 (2007). https://doi.org/10.1038/nchembio1107-687
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DOI: https://doi.org/10.1038/nchembio1107-687