One of the primary functions of the Golgi apparatus is the assembly of glycans on macromolecules destined for secretion or the plasma membrane. A recent study describes the first step toward an artificial Golgi, based on a microfluidic chip and magnetic nanoparticles.
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References
Varki, A. et al. Essentials of Glycobiology (Cold Spring Harbor Laboratories Press, Cold Spring Harbor, New York, 2009).
Esko, J.D. & Lindahl, U. J. Clin. Invest. 108, 169–173 (2001).
Martin, J.G. et al. J. Am. Chem. Soc. published online, doi:10.1021/ja903038d (10 July 2009).
Bishop, J.R., Schuksz, M. & Esko, J.D. Nature 446, 1030–1037 (2007).
Esko, J.D. & Selleck, S.B. Annu. Rev. Biochem. 71, 435–471 (2002).
Lindahl, U., Backstrom, G., Thunberg, L. & Leder, I.G. Proc. Natl. Acad. Sci. USA 77, 6551–6555 (1980).
Atha, D.H., Lormeau, J.C., Petitou, M., Rosenberg, R.D. & Choay, J. Biochemistry 24, 6723–6729 (1985).
Chen, J., Jones, C.L. & Liu, J. Chem. Biol. 14, 986–993 (2007).
Watson, M.W. et al. Anal. Chem. 78, 7877–7885 (2006).
Pinhal, M.A.S. et al. Proc. Natl. Acad. Sci. USA 98, 12984–12989 (2001).
Presto, J. et al. Proc. Natl. Acad. Sci. USA 105, 4751–4756 (2008).
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Xu, D., Esko, J. A Golgi-on-a-chip for glycan synthesis. Nat Chem Biol 5, 612–613 (2009). https://doi.org/10.1038/nchembio0909-612
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DOI: https://doi.org/10.1038/nchembio0909-612