The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.
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Rymond, B. Targeting the spliceosome. Nat Chem Biol 3, 533–535 (2007). https://doi.org/10.1038/nchembio0907-533
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DOI: https://doi.org/10.1038/nchembio0907-533
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