Peptide bond formation is catalyzed from stable aminoacyl-tRNA intermediates by several specialized proteins. A new set of these enzymes forming cyclodipeptides present the first usage of tRNAs in secondary metabolism.
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References
Gondry, M. et al. Nat. Chem. Biol. 5, 414–420 (2009).
Matsuhashi, M. et al. Proc. Natl. Acad. Sci. USA 54, 587–594 (1965).
Hedge, S.S. & Blanchard, J.S. J. Biol. Chem. 278, 22861–22867 (2003).
Fonvielle, M. et al. Nucleic Acids Res. 37, 1589–1601 (2009).
Suto, K. et al. EMBO J. 25, 5942–5950 (2006).
Dong, X. et al. Protein Sci. 16, 528–534 (2007).
Watanabe, K. et al. Nature 449, 867–871 (2007).
Rai, R. et al. EMBO Rep. 7, 800–805 (2006).
Moore, B.S. Angew. Chem. Int. Ed. 47, 7746–7759 (2008).
Kanzaki, H. et al. J. Antibiot. 53, 1257–1264 (2000).
Gondry, M. et al. Eur. J. Biochem. 268, 1712–1721 (2001).
Lautru, S. et al. Chem. Biol. 9, 1355–1364 (2002).
Belin, P. et al. Proc. Natl. Acad. Sci. USA published online, 10.1073/pnas.0812191106 (22 April 2009).
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von Döhren, H. Charged tRNAs charge into secondary metabolism. Nat Chem Biol 5, 374–375 (2009). https://doi.org/10.1038/nchembio0609-374
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DOI: https://doi.org/10.1038/nchembio0609-374
