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A QUICk look at O-GlcNAc dynamics

In addition to expanding the chemical tools for exploring O-GlcNAc protein modifications, an innovative chemical biology approach has yielded new insights into the dynamic nature of this post-translational modification in the rodent brain.

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Figure 1: The QUIC-Tag strategy for quantitative analysis of O-GlcNAc.

References

  1. Khidekel, N. et al. Nat. Chem. Biol. 3, 339–348 (2007).

    Article  CAS  Google Scholar 

  2. Khidekel, N., Ficarro, S.B., Peters, E.C. & Hsieh-Wilson, L.C. Proc. Natl. Acad. Sci. USA 101, 13132–13137 (2004).

    Article  CAS  Google Scholar 

  3. Bishop, A.C. et al. Nature 407, 395–401 (2000).

    Article  CAS  Google Scholar 

  4. Hsu, J.L., Huang, S.Y., Chow, N.H. & Chen, S.H. Anal. Chem. 75, 6843–6852 (2003).

    Article  CAS  Google Scholar 

  5. Mikesh, L.M. et al. Biochim. Biophys. Acta 1764, 1811–1822 (2006).

    Article  CAS  Google Scholar 

  6. Vosseller, K. et al. Proteomics 5, 388–398 (2005).

    Article  CAS  Google Scholar 

  7. Zachara, N.E. & Hart, G.W. Biochim. Biophys. Acta 1761, 599–617 (2006).

    Article  CAS  Google Scholar 

  8. Fischer, E.H. & Krebs, E.G.J. Biol. Chem. 216, 121–132 (1955).

    CAS  Google Scholar 

Download references

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Wells, L. A QUICk look at O-GlcNAc dynamics. Nat Chem Biol 3, 303–304 (2007). https://doi.org/10.1038/nchembio0607-303

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