Labeling endogenous proteins in their natural environment with synthetic probes represents a major challenge in chemical biology. In a recent study, an elegant traceless labeling technique has been reported that allows attachment of biophysical probes to the targeted proteins in vivo.
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Lin, Q., Lim, R. Traceless native protein labeling in mice. Nat Chem Biol 5, 275–276 (2009). https://doi.org/10.1038/nchembio0509-275
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DOI: https://doi.org/10.1038/nchembio0509-275