A chemical-genetic study indicates that modulation of neurotransmitter signaling affects the self-renewal capacity of neural stem cells in culture. Although the mechanisms of action are not resolved, the research points to a potential therapeutic target class for treatment of brain tumors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Ris
References
Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. & Clarke, M.F. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).
Bonnet, D. & Dick, J.E. Nat. Med. 3, 730–737 (1997).
O'Brien, C.A., Pollett, A., Gallinger, S. & Dick, J.E. Nature 445, 106–110 (2007).
Singh, S.K. et al. Cancer Res. 63, 5821–5828 (2003).
Diamandis, P. et al. Nat. Chem. Biol. 3, 268–273 (2007).
Al-Hajj, M. & Clarke, M.F. Oncogene 23, 7274–7282 (2004).
Pomeroy, S.L. Neuron Glia Biol. 1, 127–133 (2004).
Owens, D.F. & Kriegstein, A.R. Neuron 36, 989–991 (2002).
Lledo, P.M., Alonso, M. & Grubb, M.S. Nat. Rev. Neurosci. 7, 179–193 (2006).
Lalonde, F.M. & Myslobodsky, M. Breast 12, 280–282 (2003).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Mercola, M. Chemical probes of neural stem cell self-renewal. Nat Chem Biol 3, 246–247 (2007). https://doi.org/10.1038/nchembio0507-246
Issue Date:
DOI: https://doi.org/10.1038/nchembio0507-246
