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The integration of cell and chemical biology in protein folding

Nature Chemical Biology volume 2, pages 224–227 (2006)Cite this article

Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments.

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Figure 1: The chemical environments of eukaryotic exocytic and endocytic pathways.
Figure 2: Protein folding energy surfaces representing a square slice from the folding funnel in vitro and in vivo.

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Acknowledgements

This work was supported by US National Institutes of Health grants GM42336 to W.E.B. and AG18917 and DK46335 to J.W.K. and by the Lita Annenberg Hazen Foundation (J.W.K.) and Cystic Fibrosis Foundation (W.E.B.).

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Authors and Affiliations

  1. Department of Chemistry and The Skaggs Institute for Chemical Biology,

    Jeffery W Kelly & William E Balch

  2. Department of Cell Biology and The Institute for Childhood and Neglected Disease, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, 92130, California, USA

    Jeffery W Kelly & William E Balch

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  1. Jeffery W Kelly
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Kelly, J., Balch, W. The integration of cell and chemical biology in protein folding. Nat Chem Biol 2, 224–227 (2006). https://doi.org/10.1038/nchembio0506-224

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