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Iron-sulfur clusters as oxygen-responsive molecular switches

Nature Chemical Biology volume 3, pages 206–207 (2007)Cite this article

FNR is a global regulator of the Escherichia coli aerobic-anaerobic growth transition and relies on an [Fe-S] cluster cofactor to control its oxygen-dependent activity. Details of the chemical reaction of oxygen with the [Fe-S] cluster reveal how this cofactor is used for oxygen sensing.

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Figure 1: Triggering the [Fe-S] switch to regulate FNR.

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  1. F. Wayne Outten is in the Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA. wayne.outten@chem.sc.edu,

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  1. F Wayne Outten
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Outten, F. Iron-sulfur clusters as oxygen-responsive molecular switches. Nat Chem Biol 3, 206–207 (2007). https://doi.org/10.1038/nchembio0407-206

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