Guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The recent discovery of quadruplex-forming sequences in the 5′ untranslated regions of various proto-oncogenes suggests an important role for such sequences in inhibition of mRNA translation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kumari, S., Bugaut, A., Huppert, J. & Balasubramanian, S. Nat. Chem. Biol. 3, 218–221 (2007).
Davis, J.T. Angew. Chem. Int. Ed. 43, 668–698 (2004).
Gellert, M., Lipsett, M.N. & Davies, D.R. Proc. Natl. Acad. Sci. USA 48, 2013–2018 (1962).
Siddiqui-Jain, A., Grand, C.L., Bearss, D.J. & Hurley, L.H. Proc. Natl. Acad. Sci. USA 99, 11593–11598 (2002).
Huppert, J.L. & Balasubramanian, S. Nucleic Acids Res. 33, 2908–2916 (2005).
Todd, A.K., Johnston, M. & Neidle, S. Nucleic Acids Res. 33, 2901–2907 (2005).
Plante, I. & Provost, P. J. Biomed. Biotechnol. 2006, 16806 (2006).
Darnell, J.C. et al. Cell 107, 489–499 (2001).
Wheelhouse, R.T., Sun, D., Han, H., Han, F.X. & Hurley, L.H. J. Am. Chem. Soc. 120, 3261–3262 (1998).
Gomez, D. et al. Nucleic Acids Res. 32, 371–379 (2004).
Marin, V.L. & Armitage, B.A. J. Am. Chem. Soc. 127, 8032–8033 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Armitage, B. The rule of four. Nat Chem Biol 3, 203–204 (2007). https://doi.org/10.1038/nchembio0407-203
Issue Date:
DOI: https://doi.org/10.1038/nchembio0407-203
